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目的 评价阿仑膦酸钠、埃本膦酸钠和泰舒对去势雌性大鼠骨质疏松症的治疗效果。方法 手术切除雌性大鼠卵巢制成骨质疏松模型 ,随机分为 4组 ,即阿仑膦酸钠组、埃本膦酸钠组、泰舒组和对照组 ,分别给予相应干预药物持续处理 6个月。治疗模型给药前、给药后 2个月和 6个月 ,分别测定全身骨密度。治疗结束后 ,进行股骨干重、灰重、骨矿含量、骨生物力学和骨组织形态计量学测定。结果 阿仑膦酸盐和埃本膦酸钠组治疗 6个月后全身骨密度有明显升高 ,分别增高6 4 9%和 7% ;而泰舒组仅上升 1 7% ,对照组几无变化。埃本膦酸盐治疗后大鼠全身、腰椎骨密度及股骨干重、灰重、最大抗弯曲载荷和骨小梁面积均较其他组高。结论 埃本膦酸钠是比阿仑膦酸钠更有效的一种骨质疏松症治疗药物
Objective To evaluate the therapeutic effects of alendronate sodium, ebinate and taishu on osteoporosis in ovariectomized female rats. Methods The ovariectomized female rats were excised into osteoporosis models and randomly divided into 4 groups: alendronate sodium group, epibatidine sodium group, tiashu group and control group, which were given corresponding interventions for 6 Months. Whole body BMD was measured before treatment and 2 months and 6 months after treatment. After treatment, the femoral shaft weight, gray weight, bone mineral content, bone biomechanics and bone histomorphometry were measured. RESULTS: After 6 months of treatment, alendronate and eppendronate significantly increased whole body BMD by 69.9% and 7%, respectively, while those in Taishu group increased only by 17% and those in the control group Variety. The body weight, lumbar spine BMD, dry weight of femur, gray weight, maximum bending load and trabecular area of rats after ebenphosphonite treatment were higher than those of other groups. Conclusion Ebenzin sodium is more effective than alendronate in the treatment of osteoporosis