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目的检测乳腺癌组织中雌激素受体(ERβ)和核因子-κB(NF-κB)蛋白的表达,并探讨其意义。方法用免疫组化SP法检测82例乳腺癌组织和45例癌旁正常组织中ERβ和NF-κB蛋白的表达情况。结果①NF-κB蛋白在乳腺癌组织中阳性表达率(45.1%)高于癌旁正常组织(15.6%)(P<0.05);ERβ在乳腺癌组织中阳性表达率(25.6%)低于癌旁正常组织(64.5%)(P<0.05);②NF-κB在乳腺癌组织中表达随着淋巴结转移增高(P<0.05),ERβ的表达与组织分级呈负相关;③NF-κB和ERβ在乳腺癌组织中的表达无关(P>0.05)。结论 NF-κB在乳腺癌的发生、发展过程中发挥着重要作用,ERβ随细胞恶变发生改变。对NF-κB、ERβ表达水平的联合检测在乳腺癌的诊断、治疗及判断预后方面有一定的指导意义。
Objective To detect the expression of estrogen receptor (ERβ) and nuclear factor-κB (NF-κB) protein in breast cancer and explore its significance. Methods Immunohistochemical SP method was used to detect the expression of ERβ and NF-κB proteins in 82 breast cancer tissues and 45 normal tissues adjacent to cancer. Results 1The positive expression rate of NF-κB protein in breast cancer tissues was higher than that in adjacent normal tissues (15.6%) (P<0.05); the positive expression rate of ERβ in breast cancer tissues (25.6%) was lower than that in adjacent tissues. Normal tissues (64.5%) (P<0.05); 2NF-κB expression in breast cancer tissues increased with lymph node metastasis (P<0.05); ERβ expression was negatively correlated with tissue grade; 3NF-κB and ERβ in breast cancer The expression in the tissues was irrelevant (P > 0.05). Conclusion NF-κB plays an important role in the occurrence and development of breast cancer, and ERβ changes with the malignant transformation of cells. The combined detection of NF-κB and ERβ expression levels has a certain guiding significance in the diagnosis, treatment, and prognosis of breast cancer.