抗生素治疗急性细菌感染具有很好的疗效。但是,当前慢性感染正逐渐增加,尽管这类感染的病原菌对一定浓度的抗生素敏感,但感染却无法被治愈。细菌生物膜形成是慢性感染长期难治的主要原因。生物膜的主要特征是对抗微生物制剂和宿主防御系统产生抵抗。生物膜耐受性具有重要的临床意义。本文综述了有关慢性感染生物膜耐受性的研究进展。 Antibiotic treatment of acute bacterial infections have a good effect. However, the current chronic infection is gradually increasing. Although the infected pathogens are sensitive to a certain concentration of antibiotics, the infection can not be cured. Bacterial biofilm formation is the main reason for long-term refractory chronic infection. The main feature of biofilms is resistance to antimicrobial agents and host defense systems. Biofilm resistance has important clinical implications. This review summarizes the research progress on the tolerance of biofilms to chronic infections.