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目的探讨多种因素对TB/HIV病人临床治疗效果的影响状况,为制订TB/HIV双重感染防治工作规划提供依据。方法对10个工作较好的国家TB/HIV控制重点县治管的TB/HIV病人临床治疗与管理资料,采取单因素Logistic回归分析和多因素非条件Logistic回归分析。结果单因素Logistic回归分析:是否落实DOTS管理、发现延误、胸部病变X范围、CD4数量、抗结核治疗副反应、抗病毒治疗副反应、抗病毒治疗7个单因素对TB/HIV病人临床治疗效果的影响显著;多因素非条件Logistic回归分析:是否落实DOTS管理、发现延误、胸部病变X范围、抗病毒治疗副反应、抗病毒治疗5个单因素对TB/HIV病人临床治疗效果的影响显著。结论应早发现、早落实病人的抗结核和抗病毒治疗,落实DOTS下治疗与管理并及时处理抗结核和抗病毒治疗药物的副反应,以提高TB/HIV病人临床结核病治疗效果。
Objective To explore the influence of various factors on the clinical effect of TB / HIV patients and provide the basis for the prevention and control of TB / HIV infection. Methods The data of clinical treatment and management of TB / HIV patients under the jurisdiction of TB / HIV control key county in 10 well-working countries were analyzed by single factor Logistic regression and multivariate non-conditional Logistic regression. Results Single-factor Logistic regression analysis: Whether to implement DOTS management, delay in detection, range of thoracic lesions X, CD4 count, side effects of anti-TB treatment, side effects of anti-retroviral therapy, antiviral therapy Clinical effect of 7 single factors on TB / HIV patients ; Logistic regression analysis of multivariate non-conditional logistic regression showed that the influence of DOTS management, delay of discovery, range of thoracic lesions X, side effects of antiviral therapy and antiviral therapy on the clinical effect of TB / HIV patients were significantly affected. Conclusion Early detection and early diagnosis of tuberculosis and antiviral therapy should be carried out in patients with tuberculosis and HIV. The treatment and management of DOTS should be implemented and the side effects of anti-tuberculosis and antiviral drugs should be treated in time to improve the clinical efficacy of TB / HIV treatment.