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长期使用以葡萄糖作为渗透剂的乳酸盐透析液,最终可导致腹膜结构和功能发生不可逆变化。因而,新型透析液的研发成为近年来腹膜透析的研究热点,葡聚糖透析液是取得的最大进展之一。相对于传统透析液,葡聚糖透析液具有许多优点,诸如具备良好的生物相容性,可通过降低碳水化合物的吸收而减少代谢并发症,在增加超滤的同时改善患者液体状况,对患者的残余肾功能有保护作用等。然而,由于测量方法的局限性,会产生血糖值的假性偏高而引起不良后果。文章就葡聚糖透析液的特点及其在腹膜透析中的应用进行综述。
Long-term use of lactate dialysate with glucose as a penetrating agent can eventually lead to irreversible changes in peritoneal structure and function. Therefore, the development of new dialysate has become a research hotspot in peritoneal dialysis in recent years. Dextran dialysate is one of the biggest progress made. Dextran dialysate has many advantages over traditional dialysates such as good biocompatibility, reduced metabolic complications by reducing the absorption of carbohydrates, improved patient fluid status while increasing ultrafiltration, The residual renal function has a protective effect. However, due to the limitations of the measurement method, there is a false high of the blood sugar level with adverse consequences. The article reviews the characteristics of dextran dialysate and its application in peritoneal dialysis.