1临床资料患者,女,35岁。间断双下肢浮肿4个月,加重1周。患者于4个月前无明显诱因间断出现双下肢浮肿,休息后不能自行消退,伴发热及四肢关节疼痛,曾出现双上肢皮疹,感脱发明显,无口腔溃疡,无尿频、尿急、尿痛,尿量减少,24小时尿量约600mL,病程中有发热,T 38℃左右,发病以来体重减轻,月经不规律,自觉心慌,活动后气短,精神食欲睡眠差,前往武汉同济医院住院查 1 clinical data, female, 35 years old. Intermittent edema of lower extremities 4 months, an increase of 1 week. Patients had no obvious incentive 4 months ago intermittent edema of both lower extremities, after rest can not subside on their own, with fever and limbs and joint pain, there have been double upper extremity rash, flu and significant, no oral ulcer, no urinary frequency, urgency, dysuria , Urine output decreased, 24-hour urine output of about 600mL, duration of fever, T 38 ℃, since the onset of weight loss, irregular menstruation, consciously flustered, shortness of breath after activity, mental appetite, poor sleep, to Wuhan Tongji Hospital inpatient check