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目的 :探讨肾阳虚与下丘脑 -垂体 -睾丸轴功能的关系及补肾中药的调整作用。方法 :以醋酸可的松造成肾阳虚大鼠模型 ,取其垂体、睾丸进行透射电镜样品制备和观察。结果 :可的松致肾阳虚大鼠垂体促性腺激素分泌细胞内质网、高尔基体严重扩张 ,线粒体空化 ,细胞核固缩。睾丸曲细精管生精上皮细胞血睾屏障扩张 ,细胞中出现许多大小不等的空泡。补肾中药能够改善垂体超微结构的损伤 ,但却不能改变睾丸超微结构的损伤。结论 :补肾中药补肾温阳的作用与其对垂体促性腺激素分泌细胞超微结构损伤的改善有关
Objective: To explore the relationship between kidney yang deficiency and hypothalamic-pituitary-testicular axis function and to adjust the role of kidney-reinforcing traditional Chinese medicine. METHODS: The model of kidney-yang deficiency rat model was established by cortisone acetate. The pituitary and testis samples were prepared and observed by transmission electron microscopy. Results :Cortisone-induced gonadotrophin-secreting cells in cortisone-induced kidney deficiency rats were severely dilated in the endoplasmic reticulum, Golgi apparatus, mitochondrial cavitation, and nuclear condensation. The testicular spermatogenic epithelial cells have dilated blood and testicular barriers, and many vacuoles of varying sizes appear in the cells. Kidney-invigorating herbs can improve the ultrastructural damage of the pituitary, but it can not change the ultrastructural damage of the testis. Conclusion : The effect of kidney-reinforcing traditional Chinese medicine replenishing yang yang is related to the improvement of ultrastructure damage of pituitary gonadotropin-secreting cells