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目的考察不同处方复方丹参黏附微丸的黏附性能,从而筛选出黏附性能较为合适的处方。方法以壳聚糖、羟丙基甲基纤维素K100M(HPMCK100M)、卡波姆为黏附材料,制备不同处方的复方丹参黏附微丸,并对其黏附性能进行测定。体外黏附性能的测定采用了最小剥离力法即测定黏附微丸与猪小肠的剥离力,组织残留法即测定微丸在猪小肠的滞留数。体内黏附性能的测定采用了直接灌胃法,通过测定微丸在小肠各部位的滞留数目,计算其黏附指数。结果组织残留法试验结果在相同时间内黏附材料占比40%的微丸残留数目较黏附材料占比30%的微丸多,最小剥离力法试验结果表明黏附材料占比40%的微丸其最小剥离力较大,同组织残留法结果一致。体内黏附试验显示黏附材料占比40%的微丸其黏附指数较小,但在胃中有一定的滞留。结论当黏附材料总占比一致时,各处方之间黏附性能并没有显著性差异,黏附材料增加时其黏附性能也会增加,但会增加在胃中的滞留时间,可能会破坏方中的有效成分。
Objective To investigate the adhesion properties of different prescriptions of Salvia miltiorrhiza adherent pellets, and to select suitable prescriptions for adhesion. Methods Chitosan, hydroxypropylmethylcellulose K100M (HPMCK100M) and carbomer were used as the adhesive materials to prepare the compound prescription Salvia miltiorrhiza adhering pellets with different prescriptions, and their adhesive properties were determined. Determination of in vitro adhesion properties using the minimum peel force method that is measured adhesion peel and pig intestine peel force, the tissue residual method that is measured pellets in pig intestine retention number. The determination of adhesion properties in vivo using a direct gavage method by measuring the number of pellets in the small intestine in the number of retention, calculate the adhesion index. Results Tissue Residual Method Test Results The number of residual pellets with 40% of the sticking material in the same time was more than that with 30% of the sticking material. The minimum peeling force test showed that 40% The minimum peel force is large, consistent with the results of the tissue residual method. The in vivo adhesion test showed that the adhesion index of 40% pellets with adhesive material was small, but there was some retention in the stomach. Conclusion When the total proportion of adhesive material is consistent, the adhesive properties of the prescriptions have no significant difference. When the adhesive material increases, the adhesive properties will increase, but it will increase the retention time in the stomach, which may destroy the effective prescription ingredient.