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目的:探讨胎盘生长因子与子癎前期发病的关系。方法:检测40例子癎前期患者及20例正常晚期妊娠血清胎盘生长因子(PlGF)的水平及胎盘CD34表达,计数微血管密度(MVD)。结果:轻度子癎前期组血清PlGF为201.25±52.33pg/ml,胎盘MVD计数为45.6±4.2,重度子癎前期组分别为165.83±37.54pg/ml,40.2±3.9,两组均低于正常晚期妊娠组315.76±76.98pg/ml,58.2±4.8,差异有显著性意义(P<0.05)。结论:子癎前期患者血清PlGF及胎盘MVD显著降低,可能与子癎前期的发病有一定关系。
Objective: To explore the relationship between placental growth factor and preeclampsia. Methods: The levels of placental growth factor (PlGF) and placental CD34 were detected in 40 cases of preeclampsia and 20 cases of normal late pregnancy, and the microvessel density (MVD) was counted. Results: The serum levels of PlGF in the early stage of mild preeclampsia were 201.25 ± 52.33pg / ml, the placental MVD was 45.6 ± 4.2, and the pre-severe preeclampsia were 165.83 ± 37.54pg / ml and 40.2 ± 3.9, respectively, both of which were lower than normal The difference was significant (P <0.05) in 315.76 ± 76.98 pg / ml and 58.2 ± 4.8 in advanced pregnancy group. Conclusion: The serum levels of PlGF and placenta MVD in patients with preeclampsia are significantly lower than those in preeclampsia, which may be related to the incidence of preeclampsia.