论文部分内容阅读
目的 初步验证小肠粘膜置换膀胱移行上皮预防膀胱癌复发的理论依据。方法 作者将 17只大白鼠行小肠段移植于膀胱 ,手术后与 11只对照组大白鼠共同用N 丁基 N 4 羟基丁基亚硝胺 (BBN)进行诱发肿瘤的实验 ,并将实验结果结合有关文献作了分析研究。结果 (1)除一只大白鼠外 ,所有移植到膀胱上的小肠 ,均未发生肿瘤。 (2 )所有对照大白鼠膀胱粘膜均有肿瘤发生。结论(1)由BBN诱发膀胱肿瘤的大鼠尿液所含致癌物质可能只对特定的靶组织—膀胱移行上皮有致癌作用 ,而对小肠上皮无致癌作用。 (2 )移行上皮本身可能对尿中致癌物质敏感 ,比小肠上皮容易发生癌变 ,其机制值得进一步深入研究。
Objective To preliminarily verify the theoretical basis for the replacement of bladder transitional epithelium by small intestinal mucosa to prevent the recurrence of bladder cancer. METHODS: Seventeen rats were transplanted into the bladder in the small intestine. After surgery, 11 rats in the control group were co-incubated with N-butyl N 4 hydroxybutylamine (BBN) to induce tumors. The experimental results were combined. Relevant literature was analyzed and studied. Results (1) Except for one rat, all the small intestines transplanted to the bladder had no tumors. (2) All control rats had tumors on the bladder mucosa. Conclusion (1) Carcinogens contained in the urine of rats with bladder tumors induced by BBN may only have carcinogenic effects on the specific target tissue, bladder transitional epithelium, but have no carcinogenic effect on the small intestine epithelium. (2) The transitional epithelium itself may be sensitive to carcinogenic substances in the urine, and is more prone to canceration than the small intestine epithelium. The mechanism is worth further study.