根据抗肿瘤蒽环抗生素的分子结构,化学改造的部位可在分子的周围即C-9侧链、氨基糖部分和蒽醌发色团的D环以及分子的中心脂肪A环和与之接近的氢醌B-环等。这是考虑到蒽环抗生素的生物活性在于蒽醌发色团的缺电子以及甙元平面和氨基甙部分之间的相对方 Depending on the molecular structure of the antitumor anthracycline antibiotic, the chemically modified site may be around the molecule, ie, the C-9 side chain, the D-loop of the amino sugar moiety and the anthraquinone chromophore, and the central fatty A-ring of the molecule, Hydroquinone B-ring and the like. This is due to the fact that the biological activity of anthracycline antibiotics lies in the absence of electrons in the anthraquinone chromophore and the relative position between the aglycon plane and the aminoglycoside moiety