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血管紧张素转换酶2是一种金属钛酶,它将血管紧张素I、血管紧张素Ⅱ分别水解为血管紧张素(1~9)及具有血管舒张、抗增殖的血管紧张素(1~7)。血管紧张素转换酶2参与了肾素-血管紧张素-醛固酮系统中多种肽的代谢过程,与高血压、肾脏疾病、糖尿病等发生相关,对心脏、肾脏有一定保护作用,进一步研究其参与保护的机制,有可能为心血管病治疗提供新的靶点。
Angiotensin-converting enzyme 2 is a metallo-enzyme that hydrolyzes angiotensin I and angiotensin II to angiotensin (1 to 9) and to vasodilatory and antiproliferative angiotensin (1-7) ). Angiotensin-converting enzyme 2 is involved in the metabolism of various peptides in the renin-angiotensin-aldosterone system and is associated with the occurrence of hypertension, kidney disease, diabetes and the like, and has certain protective effects on the heart and kidney and further studies on its involvement The mechanism of protection may provide a new target for the treatment of cardiovascular diseases.