论文部分内容阅读
目的探讨新疆塔克拉玛干“沙漠人”早期肾脏功能损害的影响因素。方法应用世界卫生组织MONICA方案,随机抽取282例“沙漠人”(沙漠组)与于田县维吾尔族成年人237例(于田组)进行肾脏功能流行病学调查、膳食调查、血液及尿液生化检测等。结果沙漠组普通人群微量白蛋白尿(MAU)检出率10.5%,肾功能减退[肾小球滤过率(GFR)﹤60ml/min]检出率3.88%;高血压人群中两项指标检出率分别为18.75%、9.09%。沙漠组与于田组间收缩压、舒张压、血尿素氮、血尿酸、GFR均有显著性差异(P<0.05);多因素logistic回归分析显示,性别是“沙漠人”MAU的危险因素,低摄盐量为“沙漠人”MAU的保护因素;高龄、收缩压高、舒张压高是“沙漠人”影响GFR的危险因素。结论高龄、性别、高收缩压、高舒张压是“沙漠人”早期肾功能损害的危险因素。“沙漠人”中MAU的检出率偏高,肾功能减退的检出率为3.88%,可能与该地区极端干旱、酷热对人体的影响有关。
Objective To investigate the influencing factors of early renal impairment in Taklimakan Desert people in Xinjiang Autonomous Region. Methods A total of 282 cases of “Desert Man” (Desert Group) and 237 cases of Uygur adults in Yutian County (Yutian Group) were randomly selected from the MONICA program of World Health Organization to carry out epidemiological investigation of renal function, dietary survey, blood and Urine biochemical testing. Results The detection rate of microalbuminuria (MAU) was 10.5% and the rate of renal dysfunction (GFR <60ml / min) was 3.88% in the desert group. The two indexes in hypertension group Out rates were 18.75%, 9.09%. The systolic blood pressure, diastolic blood pressure, blood urea nitrogen, serum uric acid and GFR in the desert group and the Yutian group were significantly different (P <0.05). Multivariate logistic regression analysis showed that sex was the risk of “desert man ” MAU Factors, low salt intake for the “desert” MAU protection factors; old age, systolic blood pressure, diastolic blood pressure is “desert ” affect the risk factors of GFR. Conclusion Age, gender, high systolic pressure and high diastolic pressure are the risk factors of early renal dysfunction in “desert man ”. The detection rate of MAU in Desert Man is high, and the detection rate of renal dysfunction is 3.88%, which may be related to the impact of extreme drought and heat on the human body in this area.