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头孢三嗪(CTRX)系一种非肠道用的头孢烯类抗生素。本文介绍CTRX用于治疗新生儿各种感染症的药代动力学特性及临床效果。一、吸收与排泄 1.血浓度新生儿105例,分别一次静注CTRX10mg/kg或20mg/kg,给药30min后,其平均血浓度分别为36～42μg/ml及46～76μg/ml,以后缓缓下降,至12h后其平均血浓度分别为10～14μg/ml及13～21μg/ml。 2.血浓度半衰期(T_(1/2))新生儿105例分为0～3 d龄、4～7 d龄及8～28d龄三组,有意义的是这三组中,唯有0～3 d龄组,(不论是成熟婴儿,即出生时体重2500g以上,或早产儿,即出生时体重不满2500g)的T_(1/2)特别长,尤其是0～3 d龄组中的早产儿,
Ceftriaxone (CTRX) is a parenteral cephem antibiotic. This article describes the pharmacokinetic properties and clinical outcomes of CTRX for the treatment of neonatal infections. First, the absorption and excretion 1. Blood concentrations of 105 newborns were injected intravenously CTRX10mg / kg or 20mg / kg, 30min after administration, the average blood concentration were 36 ~ 42μg / ml and 46 ~ 76μg / ml, after Slowly decreased to 12h after the average blood concentration of 10 ~ 14μg / ml and 13 ~ 21μg / ml. The half-life of blood concentration (T_ (1/2)) 105 newborns were divided into three groups: 0 ~ 3 d, 4 ~ 7 d and 8 ~ 28 d, it is significant that only 0 The T 1/2 (especially in mature infants, ie, those with a birth weight of 2500 g or more, or premature infants, who were born with a body weight of less than 2500 g) were particularly prolonged in the ~ 3 d group, especially in the 0-3 d group premature baby,