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地高辛的治疗指数低,医院中应用地高辛的患者,中毒发生率为10～30%,其中老年、肾功能不全、慢性肺疾患和甲状腺机能低下患者更多见。放射免疫方法测定血清中地高辛的浓度可以精确地估计个体的剂量需要,多数房颤患者控制心率所需浓度在1.0和2.5nmol/l(0.8～2.0ng/l)之间。地高辛的剂型可以影响其血液浓度,许多药物可以与地高辛产生相互作用,灭吐灵和普鲁本辛能改变胃排空的速度而降低或增加地高辛的血液浓度,合并应用利尿剂常致血钾降低而使洋地黄中毒发生率增加。几种治疗心脏病的药物可使地高辛的血液浓度增加,如异博定(增加70～80%)、硝苯毗啶(增加45%)、乙胺碘呋酮(增加70%)。奎尼丁能使地高辛的平均血浓从1.1nmol/l 增加至2.0nmol/l(0.9ng/l 至1.6ng/l),据信其可能的原因之一是
Digoxin treatment index is low, the hospital application of digoxin in patients with poisoning rate of 10 to 30%, of which elderly, renal insufficiency, chronic lung disease and hypothyroidism more common. Radioimmunoassay The determination of digoxin concentrations in serum can accurately estimate individual dose requirements, with most AF patients controlling heart rate at concentrations between 1.0 and 2.5 nmol / l (0.8 to 2.0 ng / l). Digoxin formulations can affect their blood levels, many of which interact with digoxin, and metoclopramide and propbaminate can alter the rate of gastric emptying and decrease or increase the blood levels of digoxin. Combined use Diuretics often lead to increased incidence of digitalis poisoning caused by decreased serum potassium. Several treatments for heart disease increase digoxin blood levels, such as ibotine (70-80% increase), nifedipine (45% increase) and amiodarone (70% increase). Given that quinidine increases the average blood concentration of digoxin from 1.1 nmol / l to 2.0 nmol / l (0.9 ng / l to 1.6 ng / l), one of the possible causes is believed to be