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通过青蒿素对感染疟原虫小鼠溶血空斑形成细胞(PFC)和玫瑰花形成细胞(RFC)影响的实验观察表明,感染贝氏疟原虫的小鼠,在血虫率较高时,PFC、RFC 反应受到严重抑制。此时用青蒿素治疗(每天300mg/kg×7天),杀灭血中原虫后测定 PFC、RFC,反应逐渐恢复;以氯喹治疗组为对照,两组间无明显差异。并对疟原虫感染后小鼠腹腔巨噬细胞在免疫反应中起的作用,做了初步的探讨。
Experimental observations of the effects of artemisinin on haemolytic plaque-forming cells (PFC) and rose forming cells (RFCs) in mice infected with Plasmodium falciparum showed that in mice infected with Plasmodium berghei, PFC was observed at high blood worm rates. The RFC reaction was severely inhibited. At this time, treatment with artemisinin (300 mg/kg per day for 7 days), killing the blood protozoa, measuring PFC, RFC, the reaction gradually recovered; chloroquine treatment group as a control, there was no significant difference between the two groups. The role of mouse peritoneal macrophages in the immune response after Plasmodium infection was initially discussed.