乌司他丁（ UTI）在临床上作为治疗急性胰腺炎、急性循环衰竭的药物已得到广泛应用。作为一种广谱的蛋白酶抑制剂，UTI具有很强的水解酶抑制活性，能够稳定溶酶体膜、清除氧自由基及抑制炎症介质的释放，减轻细胞与组织损伤，改善休克时的循环和组织灌注状态，还可改善手术刺激对内脏器官与组织细胞的损伤，对肾、肺、肝、心、脑等多个器官具有保护作用。“,”Ulinastatin ( UTI) has been widely applied in clinical,as a drug treatment for acute pancrea-titis and acute circulatory failure .As a protease inhibitor with broad spectrum , UTI has a strong inhibitory activity of the hydrolase and has protective effects on multiple organs,such as kidney,lung,heart,liver,cere-bra,by inhibiting the activity of protease and lysosomal enzymes,eliminating oxygenic free radical,suppress-ing the release of inflammatory cytokines,improving microcirculation and perfusion,it can also improve the injury to internal organs and cells stimulated by surgeries .