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近年来左旋咪唑作为一种免疫增强剂已被广泛应用于临床。文献报告有胃肠道反应、皮疹、流感样综合征、粒细胞减少等副反应,特别是粒细胞减少后果比较严重。近年来我们临床上用得较多,现将长期服用左旋咪唑的患者100例,对其副作用进行分析、讨论。 100例中类风湿性关节炎50例,复发性口腔溃疡30例,白塞氏综合征5例,其它15例。服用剂量每日150毫克,分3次口服,根据病情每周连服2、3、4天不等。最小总剂量为2.4克,最大总剂量为34克,平均17.6克。治疗期间一般不用其它药物。治疗中15例胃肠反应5例,皮疹2例,严重口干、唇部皲裂3例,严重乏力2例,流感样综合征合并粒细胞减少2例,精神兴奋1例。发生不同程度的副反应。2例粒细胞减少的患者,一例第一次服药5个月中未见异常,停药半年后在接受第二次用药的次日,
In recent years, levamisole as an immune enhancer has been widely used in clinical. Reported in the literature of gastrointestinal reactions, rash, influenza-like syndrome, neutropenia and other side effects, especially the consequences of granulocytopenia more serious. In recent years, we use more clinically, now long-term use of levamisole in 100 patients, their side effects were analyzed and discussed. 100 cases of rheumatoid arthritis in 50 cases, 30 cases of recurrent oral ulcer, Behcet’s syndrome in 5 cases, the other 15 cases. Taking a dose of 150 mg daily, orally 3 times a day, according to the disease even served 2, 3, 4 days a week. The minimum total dose was 2.4 grams and the maximum total dose was 34 grams with an average of 17.6 grams. During the treatment generally do not have other drugs. In the treatment of 15 cases of gastrointestinal reactions in 5 cases, 2 cases of rash, severe dry mouth, lip chapped in 3 cases, severe fatigue in 2 cases, influenza-like syndrome with neutropenia in 2 cases, 1 case of mental excitement. There are different degrees of side effects. Two patients with neutropenia, one case of the first five months of taking no abnormalities, stopping six months after receiving the second day of medication,