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用戊二醛和甲醛甲酚分别处理鼠磨牙活髓切断术后髓断端,并观察术后3～28天根髓及根尖周组织的变化。结果发现甲醛甲酚处理后,炎症达根髓的中1/3或根尖1/3,其余大部根髓坏死,个别根尖周组织见到慢性炎症细胞浸润;戊二醛处理后,炎症仅局限于接触区,且有纤维结缔组织包绕和似牙本质桥形成,其余牙髓和根尖周组织正常。本实验结果支持临床牙髓治疗中,用戊二醛代替甲醛甲酚。
The medulla oblongata was treated with glutaraldehyde and formaldehyde cresol, respectively. The changes of the root pulp and periapical tissue were observed 3 ~ 28 days after operation. The results showed that formaldehyde cresol treatment, the inflammation of the root of medullary 1/3 or root tip 1/3, most of the other root necrosis, some of the periapical tissue to see chronic inflammatory cell infiltration; glutaraldehyde treatment, inflammation Only confined to the contact area, and fibrous connective tissue surrounding and dentin bridge formation, the rest of the pulp and periapical tissue is normal. The results of this study support the clinical endodontic treatment, with glutaraldehyde instead of formaldehyde cresol.