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目的通过动态血糖监测系统(CGMS)联合胰岛素泵(CSII)对2型糖尿病患者生活质量的远期影响观察和分析,以期降低血糖波动、低血糖事件发生率,从而改善患者生活质量。方法 2011年3月—2012年4月,选取本院门诊及住院120例新诊断的2型糖尿病者,且根据患者就诊次序、参考随机数字表法、按照1∶1∶1比例分为三组,观察组给予CGMS+CSII联合治疗;对照Ⅰ组指血监测+CSII治疗;对照Ⅱ组指血监测+每日多次注射胰岛素(MSII)治疗,且对三组患者低血糖事件、糖化血红蛋白及平均血糖波动情况和不同时间段生活质量进行观察和所得数据的统计学处理分析。结果低血糖事件和严重低血糖事件统计:对照Ⅰ组、对照Ⅱ组与观察组相比P<0.05;糖化血红蛋白及平均血糖波动情况对比:对照Ⅰ组、对照Ⅱ组与观察组相比P<0.05;不同时间段生活质量评分相比:3个月时,对照Ⅰ组,对照Ⅱ组与观察组相比P<0.05;6个月时,对照Ⅰ组与观察组相比P<0.05,对照Ⅱ组与观察组相比P<0.01。结论 CGMS联合CSII更加符合个体化的需求,从而减少、延缓糖尿病慢性并发症的发生,进而从远期来看,能明显改善患者生活质量。
Objective To observe and analyze the long-term quality of life of patients with type 2 diabetes through dynamic glucose monitoring system (CGMS) combined with insulin pump (CSII) in order to reduce the incidence of blood glucose and hypoglycemic events and thus improve the quality of life of patients. Methods From March 2011 to April 2012, 120 newly diagnosed type 2 diabetics in our hospital and inpatient department were selected and divided into three groups according to the order of patients’ treatment according to the random number table method according to the ratio of 1: 1: 1 , The observation group was given CGMS + CSII combined treatment; control group Ⅰ refers to the blood monitoring + CSII treatment; control Ⅱ group refers to the blood monitoring + daily multiple injections of insulin (MSII) treatment, and the three groups of patients with hypoglycemia, glycosylated hemoglobin and Average blood glucose fluctuations and quality of life at different time points were observed and the statistical analysis of the data obtained. Results Hypoglycaemia and severe hypoglycemia events: control Ⅰ group, control Ⅱ group compared with the observation group P <0.05; HbA1c and average blood glucose fluctuation comparison: control Ⅰ group, control Ⅱ group compared with the observation group P < 0.05). Compared with the observation group, the control groupⅠand the control groupⅡwere significantly lower than those of the observation group at 3 months (P <0.05); at 6 months, the control groupⅠwas significantly lower than that of the observation group Ⅱ group compared with the observation group P <0.01. Conclusions CGMS combined with CSII is more in line with individual needs, thus reducing and delaying the occurrence of chronic complications of diabetes, and then in the long run, can significantly improve the quality of life of patients.