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目的探讨高血压合并颈动脉粥样硬化患者血清中促甲状腺激素(TSH)和C-反应蛋白(CRP)水平与高血压患者颈动脉病变程度及脑血管事件发生的关系。方法选取本院2015年11月-2016年11月收治的85例高血压患者作为研究对象,检测患者血清中促甲状腺激素和CRP水平与患者颈动脉病变程度,采用Logistics回归分析探讨血清中TSH和CRP水平与患者脑血管事件发生的关系。结果低水平CRP、TSH组患者内-中膜厚度、斑块面积均低于相应高水平组患者,差异均有统计学意义(P<0.05)。低水平CRP、TSH组软斑块发生率低于对应高水平组患者,而硬斑块发病率高于对应高水平组患者,差异均有统计学意义(P<0.05)。Logistics回归分析结果提示,TSH、软斑块、CRP是患者脑血管事件的独立风险因素(P<0.05)。结论血清中TSH和CRP水平高的患者颈动脉病变越严重,脑血管事件风险更高。
Objective To investigate the relationship between thyroid-stimulating hormone (TSH) and C-reactive protein (CRP) in patients with hypertension and carotid atherosclerosis and the severity of carotid artery disease and cerebrovascular events in patients with hypertension. Methods Eighty-five hypertensive patients admitted to our hospital from November 2015 to November 2016 were enrolled in this study. Serum levels of thyroid-stimulating hormone (CRP) and CRP were measured in patients with carotid artery lesions. Logistics regression analysis was used to investigate the correlation between serum TSH The Relationship between CRP Level and Cerebrovascular Events in Patients. Results In patients with low CRP and TSH, the intima - media thickness and plaque area were lower than those in the corresponding high level group (P <0.05). The incidence of soft plaque in low CRP and TSH group was lower than that in corresponding high level group, while the incidence of hard plaque was higher than that in corresponding high level group (P <0.05). Logistics regression analysis suggested that TSH, soft plaque and CRP were independent risk factors of cerebrovascular events in patients (P <0.05). Conclusion Serum levels of TSH and CRP in patients with carotid artery disease more serious, higher risk of cerebrovascular events.