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目的探讨脑微出血相关危险因素并评价对患者认知功能的影响。方法 84例腔隙性脑梗死患者,根据是否存在脑微出血分为研究组[39例,经磁共振成像(MRI)检查示存在脑微出血]和对照组(45例,未见脑微出血)。收集两组生化指标,明确独立危险因素;并评价两组患者认知功能差异。结果两组患者甘油三酯、空腹血糖、肌酐指标比较差异无统计学意义(P>0.05);研究组总胆固醇为(4.19±0.95)mmol/L,显著低于对照组的(4.96±0.87)mmol/L,差异具有统计学意义(P<0.05);研究组同型半胱氨酸为(14.15±4.51)μmol/L,显著高于对照组的(9.16±2.48)μmol/L,差异具有统计学意义(P<0.01)。经Logistic回归分析显示同型半胱氨酸为脑微出血独立危险因素。研究组患者平均认知功能评分为(23.15±2.41)分,显著低于对照组的(27.56±1.22)分,差异具有统计学意义(t=10.790,P<0.01)。结论脑微出血患者独立危险因素为同型半胱氨酸,脑微出血可诱发认知功能障碍。但是,由于本次研究样本量较小,应在扩大样本基础上进一步研究。
Objective To explore the impact of brain micro-hemorrhage-related risk factors and evaluation of cognitive function in patients. Methods A total of 84 cases of lacunar infarction were divided into study group (39 cases, cerebral micro-hemorrhage by MRI) and control group (45 cases, no cerebral micro-hemorrhage ). Two groups of biochemical indexes were collected to clarify the independent risk factors; and to evaluate the difference of cognitive function between the two groups. Results There was no significant difference in triglyceride, fasting blood glucose and creatinine between the two groups (P> 0.05). The total cholesterol in the study group was (4.19 ± 0.95) mmol / L, which was significantly lower than that in the control group (4.96 ± 0.87) mmol / L, the difference was statistically significant (P <0.05). The homocysteine in the study group was (14.15 ± 4.51) μmol / L, which was significantly higher than that in the control group (9.16 ± 2.48) μmol / L Significance (P <0.01). Logistic regression analysis showed that homocysteine was an independent risk factor for cerebral hemorrhage. The average cognitive function score of the study group was (23.15 ± 2.41) points, which was significantly lower than that of the control group (27.56 ± 1.22) points, the difference was statistically significant (t = 10.790, P <0.01). Conclusion The independent risk factor for cerebral micro-hemorrhage is homocysteine. Cerebral micro-hemorrhage can induce cognitive dysfunction. However, due to the small sample size of this study, further study should be conducted on the basis of expanding samples.