目的:探讨当归对阴虚哮喘小鼠的平喘作用及对水通道蛋白1表达的影响。方法:将小鼠随机分为正常对照组、模型对照组、地塞米松组、3个当归剂量组、当归与地塞米松组,通过注射卵清白蛋白(OVA)致敏、吸入OVA激发的方法复制哮喘小鼠模型,实验后期给予甲状腺素以复制阴虚哮喘BALB/c小鼠模型,在考察小鼠自主活动、血清c AMP等阴虚指标的基础上,观测当归对哮喘发作及其程度、肺功能、肺液清除功能、血清IL-13与TNF-α、肺组织AQP1及其基因表达的影响。结果:2、4、8g/kg当归可明显抑制哮喘发作及其症状,改善肺功能,降低自主活动次数及血清c AMP、IL-13与TNF-α水平,促进肺组织AQP1及其基因(1.29±0.08、1.32±0.09、1.35±0.11,模型对照组为1.00±0.00)的表达。同时,当归与地塞米松配伍后对改善肺功能、调节AQP1及其基因表达等方面有一定的协同作用。结论:当归对阴虚哮喘具有一定的治疗作用,调节AQP1及其基因表达而促进水代谢平衡是其作用机制之一。 Objective: To investigate the antiasthmatic effect of Angelica sinensis on asthenospermia mice and its effect on aquaporin 1 expression. Methods: The mice were randomly divided into normal control group, model control group, dexamethasone group, three angelica dose groups, Angelica sinensis and dexamethasone group, sensitized by ovalbumin (OVA) injection and OVA challenge The model of asthmatic mice was duplicated and the thyroxine was administered to replicate the BALB / c mouse model of asthenospermia in the later experiment. Based on the investigation of the indexes of spontaneous activity and serum c AMP in mice, the incidence of asthma and its degree, Lung function, pulmonary fluid clearance, serum IL-13 and TNF-α, lung tissue AQP1 and their gene expression. Results: 2,4,8 g / kg Angelica Sinensis could significantly inhibit the onset of asthma and its symptoms, improve pulmonary function, reduce the number of spontaneous activity and the levels of c AMP, IL-13 and TNF-α, and promote the expression of AQP1 and its gene ± 0.08, 1.32 ± 0.09, 1.35 ± 0.11, 1.00 ± 0.00 in model control group). At the same time, Angelica and dexamethasone compatibility have certain synergistic effects on improving pulmonary function and regulating AQP1 and its gene expression. Conclusion: Angelica sinensis has a certain therapeutic effect on asthma of yin deficiency. Regulation of AQP1 and its gene expression to promote water metabolism balance is one of its mechanisms.