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目的探讨急性冠状动脉综合征(ACS)患者血清脑钠肽(BNP)水平与冠状动脉病变严重程度的关系。方法采用荧光免疫法分别检测42例ACS患者、20例稳定性心绞痛(SA)患者及20例健康对照者的血清BNP水平,ACS患者按冠状动脉造影结果分为单支、双支和三支病变组,分析各组之间BNP水平的差异。结果 ACS组BNP水平明显高于SA组及健康对照组(P<0.01);SA组与对照组比较差异无统计学意义(P>0.05);ACS组随病变动脉支数的增加BNP水平也相应增高,差异有统计学意义(P<0.01)。结论血清BNP水平与冠状动脉病变严重程度呈正相关,可作为ACS患者危险评估的指标。
Objective To investigate the relationship between serum brain natriuretic peptide (BNP) and the severity of coronary artery disease in patients with acute coronary syndrome (ACS). Methods The levels of serum BNP in 42 patients with ACS, 20 patients with stable angina pectoris (SA) and 20 healthy controls were detected by fluorescence immunoassay. Patients with ACS underwent coronary angiography and were divided into single, double and triple vessel disease Groups were analyzed for differences in BNP levels between groups. Results The BNP level in ACS group was significantly higher than that in SA group and healthy control group (P <0.01). There was no significant difference between SA group and control group (P> 0.05). The ACS group also had a corresponding increase in BNP level Increased, the difference was statistically significant (P <0.01). Conclusions Serum BNP level is positively correlated with the severity of coronary artery disease and may be used as an index of risk assessment in patients with ACS.