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目的探讨不同剂量辛伐他汀治疗高脂血症的临床疗效及安全性。方法将我院给予辛伐他汀治疗的108例老年高脂血症患者随机分为两组,观察辛伐他汀40mg/d(观察组)与20mg/d(对照组)治疗的临床效果及不良反应。结果观察组治疗后TC、TG、LDL-C水平均低于对照组(P<0.01),HDL-C水平高于对照组(P<0.01);两组不良反应发生率比较差异不显著(P>0.05)。结论大剂量(40mg/d)辛伐他汀治疗老年高脂血症疗效优于小剂量(20mg/d),且同样安全可靠。
Objective To investigate the clinical efficacy and safety of different doses of simvastatin in the treatment of hyperlipidemia. Methods 108 elderly patients with hyperlipidemia treated with simvastatin in our hospital were randomly divided into two groups. The clinical effects and side effects of simvastatin 40 mg / d (observation group) and 20 mg / d (control group) . Results The levels of TC, TG and LDL-C in the observation group were lower than those in the control group (P <0.01), and the levels of HDL-C in the observation group were higher than those in the control group (P <0.01). There was no significant difference in the incidence of adverse reactions between the two groups > 0.05). Conclusions High-dose (40mg / d) simvastatin is superior to low-dose (20mg / d) in the treatment of senile hyperlipidemia, and is equally safe and reliable.