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本发明涉及合成二氢吡啶和吡咯类杂环化合物的新方法,该方法是在有机溶剂中,用亚胺与炔作为底物,在铜(I)催化条件下发生多组分反应,同时得到二氢吡啶和吡咯类杂环化合物。所述的合成方法起始原料、催化剂便宜易得,原子经济效益高,杂环产率较高,官能团取代类型受限较小,反应条件温和,操作简单等优点。本发明所涉及的两种杂环结构如结构式I,II所示。其中:R1选自:苯环,被C1~C3烷基,OMe,NO2,
The present invention relates to a novel process for the synthesis of dihydropyridine and pyrrole heterocyclic compounds by the reaction of a multicomponent reaction of copper (I) with an imine and an alkyne as a substrate in an organic solvent while obtaining Dihydropyridine and pyrrole heterocyclic compounds. The synthesis method has the advantages of convenient starting materials, cheap and convenient catalyst, high atom economic efficiency, high yield of heterocyclic rings, limited substitution of functional groups, mild reaction conditions and simple operation. Two kinds of heterocyclic structures involved in the present invention are shown as structural formulas I and II. Wherein: R1 is selected from the group consisting of a benzene ring substituted with C1-C3 alkyl, OMe, NO2,