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目的从循证医学角度评价腹腔镜胃肠间质瘤切除术(LAP)的安全性和有效性。方法收集2004年1月至2014年3月发表的有关LAP和开腹胃肠间质瘤切除术(OPEN)对比的英文文献,按纳入和排除标准筛选文献、提取资料并进行质量评价后,利用Review Manager 5.2软件进行Meta分析。结果共纳入12篇文献(719例病人),其中LAP组345例,OPEN组374例。荟萃分析结果显示,与OPEN相比,LAP术后排气时间、进流质时间和住院时间更短(均P<0.05),术后并发症发生率及复发率更低(均P<0.05),而手术时间、术中出血量差异均无统计学意义(均P>0.05)。结论行LAP治疗胃肠间质瘤安全可行,且具有良好的近期疗效。
Objective To evaluate the safety and efficacy of laparoscopic gastrointestinal stromal tumor resection (LAP) from the perspective of evidence-based medicine. Methods The English literatures about the contrast between LAP and open gastrointestinal stromal tumor (OPEN) published from January 2004 to March 2014 were collected. After selecting the literature according to inclusion and exclusion criteria, extracting the data and evaluating the quality, Review Manager 5.2 software for meta-analysis. Results A total of 12 articles (719 patients) were enrolled, including 345 in the LAP group and 374 in the OPEN group. Meta-analysis showed that, compared with OPEN, LAP postoperative exhaust time, admission time and hospital stay shorter (all P <0.05), postoperative complications and recurrence rate was lower (all P <0.05) There was no significant difference in operation time and intraoperative blood loss (all P> 0.05). Conclusion LAP treatment of gastrointestinal stromal tumors safe and feasible, and has good short-term efficacy.