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目的观察不同剂量瑞舒伐他汀钙对合并高脂血症的青年脑梗死患者的临床疗效。方法选取住院治疗的青年脑梗死患者100例,随机分为两组:A组行小剂量瑞舒伐他汀钙+常规治疗,B组行大剂量瑞舒伐他汀钙+常规治疗。分别于治疗前,治疗后14 d、6个月进行NIHSS评分、BI评分,检测血脂水平,每月查肝肾功能、心肌酶、血糖评价药物不良反应。结果治疗14 d及6月后两组进行比较,NIHSS评分B组均低于A组(P=0.0377,P=0.0291),BI评分B组均高于A组(P=0.0121,P=0.0238)。治疗14 d后两组甘油三脂(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、非高密度脂蛋白胆固醇(non-HDL-C)比较,B组低于A组(P=0.0083,P=0.0040,P=0.0205,P=0.0185),治疗6月后两组TG、TC、LDL-C、non-HDL-C比较,B组均低于A组(P=0.0046,P=0.0008,P=0.0000,P=0.0041)。两组不良反应发生率分别为4.00%、6.00%,差异无统计学意义(χ~2=0.323,P=0.851)。结论大剂量瑞舒伐他汀钙治疗青年脑梗死的临床疗效确切,不良反应轻微,可长期应用。
Objective To observe the clinical efficacy of different doses of rosuvastatin calcium in patients with cerebral infarction complicated by hyperlipidemia. Methods 100 hospitalized young patients with cerebral infarction were randomly divided into two groups: group A received low-dose rosuvastatin calcium plus conventional therapy and group B received high-dose rosuvastatin calcium plus conventional therapy. NIHSS score, BI score, blood lipid level, liver and kidney function, myocardial enzymes and blood sugar were evaluated before treatment, 14 days and 6 months after treatment respectively. Results The scores of NIHSS in group B were lower than those in group A (P = 0.0377, P = 0.0291) and those in BI group were higher than those in group A on the 14th day and the 6th day after treatment (P = 0.0121, P = 0.0238) . The levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and non-HDL-C in the two groups after treatment for 14 days were lower than those in group B (P = 0.0083, P = 0.0040, P = 0.0205, P = 0.0185). The levels of TG, TC, LDL-C and non-HDL-C in the two groups after treatment for 6 months were lower in group B than in group A (P = 0.0046, P = 0.0008, P = 0.0000, P = 0.0041). The incidence of adverse reactions in the two groups were 4.00% and 6.00%, respectively, with no significant difference (χ ~ 2 = 0.323, P = 0.851). Conclusion The high dose of rosuvastatin calcium in the treatment of young patients with cerebral infarction has definite curative effect, mild side effects and long-term application.