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目的:观察丹参川芎嗪注射液联合甲钴胺治疗糖尿病周围神经病变(DNP)的临床疗效。方法:100例DNP患者随机分成观察组(丹参川芎嗪注射液联合甲钴胺)与对照组(甲钴胺)各50例,两组病例均给予饮食控制、合理运动,口服降糖药或注射胰岛素,血糖均控制在理想水平,疗程为4周。观察两组病例的临床疗效及治疗前后感觉神经传导速度(SCV)及运动神经传导速度(MCV)的变化。结果:观察组患者症状、体征以及神经传导速度均较对照组明显改善(P<0.05)。结论:丹参川芎嗪注射液联合甲钴胺治疗DNP疗效肯定,值得临床推广应用。
Objective: To observe the clinical effect of ligustrazine injection and mecobalamin in the treatment of diabetic peripheral neuropathy (DNP). Methods: One hundred patients with DNP were randomly divided into observation group (Salviae miltiorrhizae ligustrazine combined with mecobalamin) and control group (Methylcobalamin) 50 cases. Both groups were given diet control, exercise, oral hypoglycemic agents or injection Insulin, blood glucose were controlled at the ideal level, treatment for 4 weeks. The clinical efficacy and the changes of sensory nerve conduction velocity (SCV) and motor nerve conduction velocity (MCV) before and after treatment were observed in two groups. Results: The symptoms, signs and nerve conduction velocity in the observation group were significantly improved compared with the control group (P <0.05). Conclusion: Salviae miltiorrhizae ligustrazine injection combined with methylcobalamin treatment of DNP certainly effect, it is worthy of clinical promotion and application.