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目的 :研究脑血康片的长期毒性。方法 :用♀和♂大鼠进行口服给药 6 0天及恢复期 14天的毒性研究。结果 :研究期间未发生与试验药物相关的死亡 ,对大鼠体重、摄食量、一般行为没有明显影响 ;本品 1.35g/kg能减少血小板数和延长凝血时间 ,0 .6 75g/kg能延长雄鼠凝血时间和降低血小板数。停药 14天后 ,与对照组比较无显著性差异 ,其余指标与正常对照组比较均无显著性差异 ;血液生化学没有与试验药物相关的变化 ;心电图没有与药物相关的变化。结论 :脑血康片毒性较低 ,是一较安全的治疗药物
Objective: To study the long-term toxicity of Naoxuekang Tablets. METHODS: Toxicity studies were conducted with oral administration of sputum and sputum rats for 60 days and recovery period of 14 days. Results: There was no death associated with the test drug during the study period. There was no significant effect on the body weight, food intake, and general behavior of the rats. The product 1.35 g/kg reduced platelet counts and prolonged clotting time, and 0.675 g/kg could prolong Male mice clotted and reduced platelet counts. After 14 days of discontinuation, there was no significant difference between the control group and the control group. There was no significant difference between the other indicators and the normal control group; blood biochemistry did not change with the test drug; there was no drug-related change in the ECG. Conclusion : Naoxinkang tablets are less toxic and safer