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目的观察右丙亚胺在治疗蒽环类药物诱发化疗性静脉炎中的安全性及有效性。方法65岁男性急性髓细胞白血病(M2a)患者静滴蒽环类药物后,左手背出现红肿、疼痛,先后给予硫酸镁外敷、芦荟外敷、土豆外敷,无效,后静脉注射右丙亚胺治疗(500mg,连续5d);38岁男性MDS转急性髓细胞白血病患者给予蒽环类药物后左手背出现红肿、疼痛,即静脉注射右丙亚胺治疗(500mg,连续5d)。临床随访(1个月)评定疗效。结果第1例应用右丙亚胺后4d疼痛减轻,7d红肿消退;第2例给予右丙亚胺治疗次日疼痛减轻,3d红肿消退。2例患者除局部留有轻度色素沉着外,手及前臂功能无影响。结论右丙亚胺治疗蒽环类药物诱发静脉炎行之有效,尽早应用,疗效更佳。
Objective To observe the safety and efficacy of dexrazoxane in the treatment of anthracycline-induced chemotherapy phlebitis. Methods Patients with acute myeloid leukemia (M2a) in a 65-year-old man presented with redness and pain on their left back with intravenous administration of magnesium sulfate, external application of Aloe, external application of potatoes, 500mg, continuous 5d); 38-year-old MDS patients with acute myeloid leukemia anthracycline after the left back showed swelling, pain, that is, intravenous injection of propylamine (500mg, continuous 5d). Clinical follow-up (1 month) assessment of efficacy. Results In the first case, the pain relief was relieved 4 days after application of dexrazoxane and the redness was resolved on the 7th day. In the second case, dexrazoxane treatment reduced the pain on the next day, and the 3d redness subsided. In addition to local mild hypopigmentation in 2 patients, there was no effect on hand and forearm function. Conclusion Right-deprotein treatment of anthracycline-induced phlebitis is effective, as soon as possible, the effect is better.