目的检测固有样淋巴细胞、αβT细胞、B2细胞在非小细胞肺癌(NSCLC)患者和正常人体内的分布情况及相关性。方法收集16例正常对照和5例NSCLC初诊患者和15例病情稳定患者外周血,采用流式细胞术检测外周血淋巴细胞中,恒定型自然杀伤T(i NKT)细胞、γδT细胞、B1细胞及αβT细胞、B2细胞的比例。结果病情稳定组的i NKT细胞比例显著低于对照组和初诊患者组,而αβT细胞比例显著高于对照人群;初诊患者组的γδT细胞显著高于病情稳定组;初诊患者组B1细胞比例明显低于对照组。病情稳定组i NKT细胞和γδT细胞呈正相关;病情稳定组和对照组B1和B2细胞呈正相关。结论NSCLC患者外周血固有样淋巴细胞亚群失衡。 Objective To detect the distribution and correlation of innate lymphoid cells, αβ T cells and B2 cells in patients with non-small cell lung cancer (NSCLC) and normal individuals. Methods Peripheral blood was collected from 16 normal controls and 5 newly diagnosed NSCLC patients and 15 stable patients. Flow cytometry was used to detect the expression of i NKT cells, γδT cells and B1 cells in peripheral blood lymphocytes αβ T cells, B2 cells. Results The proportion of i NKT cells in the stable condition group was significantly lower than that in the control group and newly diagnosed patients, while the ratio of αβ T cells was significantly higher than that in the control group. The γδT cells in the newly diagnosed group were significantly higher than those in the stable condition group. In the control group. Stable condition group i NKT cells and γδ T cells was positively correlated; stable disease group and control group B1 and B2 cells were positively correlated. Conclusion The imbalance of intrinsic lymphoid cells in NSCLC patients.