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目的:探讨平消胶囊对表柔比星抗人乳腺癌细胞SKBR-3活性的影响。方法:分别将1、2.5和5g/L的平消胶囊乙醇提取物加入含表柔比星0.005、0.05、0.1和0.5mg/L的培养液,组成12组混合培养液用以培养人乳腺癌细胞SKBR-3,72h后用MTT技术检测各组的抑瘤率。结果:1、2.5和5g/L组平消胶囊乙醇提取物对人乳腺癌细胞SKBR-3的抑瘤率分别为10.87%、20.86%和33.90%;0.005、0.05、0.1和0.5mg/L组表柔比星的抑瘤率分别为9.33%、24.57%、31.77%和48.97%;12组平消胶囊提取物和表柔比星混合液抑瘤率分别为31.63%、43.03%、46.80%、63.72%、49.25%、54.70%、55.19%、68.61%、55.19%、62.25%、63.72%和72.25%。结论:平消胶囊提取物对表柔比星抗人乳腺癌细胞SKBR-3具有增效作用。
Objective: To investigate the effect of Pingxiao capsule on the activity of epirubicin anti-human breast cancer cell line SKBR-3. Methods: 1, 2.5 and 5g / L of Pingxiao capsule ethanol extract were added to epirubicin 0.005,0.05,0.1 and 0.5mg / L of the culture medium to form a group of 12 mixed medium for the culture of human breast cancer Cell inhibition rate of SKBR-3 cells was detected by MTT assay 72h later. Results: The inhibitory rates of ethanol extract of Pingxiao capsule on human breast cancer cell line SKBR-3 were 10.87%, 20.86% and 33.90% respectively in the groups of 1, 2.5 and 5g / L, 0.005,0.05,0.1 and 0.5mg / L The inhibition rates of epirubicin were 9.33%, 24.57%, 31.77% and 48.97%, respectively. The inhibitory rates of the two groups were 31.63%, 43.03% and 46.80%, respectively. 63.72%, 49.25%, 54.70%, 55.19%, 68.61%, 55.19%, 62.25%, 63.72% and 72.25%. Conclusion: Pingxiao capsule extract has synergistic effect on epirubicin anti-human breast cancer cell line SKBR-3.