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目的评价环孢素A(CsA)与化疗方案联合应用治疗复发及难治性急性白血病的效果。方法对8例复发及难治性急性白血病进行诱导化疗。化疗方案由CsA、阿克拉霉素、或异环磷酰胺等组成。结果5例患者获完全缓解，另3例只进行了1个疗程化疗，可评价的2例均获部分缓解。所报告方案的毒性反应主要为骨髓抑制。结论化疗伍用CsA可能是治疗复发及难治急性白血病的有效方案。
Objective To evaluate the efficacy of cyclosporine A (CsA) combined with chemotherapy in the treatment of relapsed and refractory acute leukemia. Methods Eight patients with relapsed and refractory acute leukemia were treated with induction chemotherapy. The chemotherapy regimen consists of CsA, aclarubicin, or ifosfamide. Results Five patients achieved complete remission, and the other three patients received only one course of chemotherapy. Two of the evaluable patients received partial remission. The toxicity of the reported protocol was mainly myelosuppression. Conclusion Chemotherapy with CsA may be an effective treatment for relapsed and refractory acute leukemia.