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目的 探讨帕金森病 (Parkinson’sdisease,PD)常规MPI的影像学表现特点和在常规MRI上测量黑质致密带 (parscompactaofsubstantianigra,SNc)宽度对PD的诊断价值。 方法 对 6 0例PD患 (Hoehn -Yahr分级为Ⅰ～Ⅱ级 38例、Ⅲ级 14例、Ⅳ级 8例 )和 6 0例正常老年人对照组均行MPI检查 ,分析PD患者的常规MPI影像学表现 ,并在常规轴位T2 WI上 ,对PD患者和对照组进行黑质致密带宽度测量。结果 皮质下白质高信号和脑萎缩在PD组比正常老年人对照组更常见 ,PD组比正常老年人对照组SNc宽度显变窄 ,并且PD患者随病情加重其SNc宽度更加变窄。结论 PD常规MRI的影像学表现不具有诊断上的特异性 ,但的常规MRI上测量SNc宽度是诊断PD的一个可靠方法。
Objective To investigate the imaging features of conventional MPI in Parkinson’s disease (PD) and to evaluate the diagnostic value of PD in patients with Parkinson’s disease (PD) by measuring the breadth of substantia nigra pars compacta (SB) on conventional MRI. Methods Sixty PD patients (Hoehn-Yahr grade Ⅰ ~ Ⅱ 38 cases, Ⅲ grade 14 cases, Ⅳ grade 8 cases) and 60 cases of normal control group were examined by MPI, PD patients with conventional MPI Imaging findings, and in the conventional axial T2 WI, PD patients and control group were measured density of substantia nigra tape. Results The subcortical white matter hyperintensities and brain atrophy were more common in the PD group than in the control group. The SNc width of the PD group was narrower than that in the control group. The SNc width of the PD group was more narrowed with the progression of the disease. Conclusion The imaging findings of PD conventional MRI do not have diagnostic specificity. However, the measurement of SNc width on conventional MRI is a reliable method to diagnose PD.