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目的探讨老年性EBV阳性弥漫性大B细胞淋巴瘤(EBV+DLBCL)临床病理特征。方法回顾2010-01—2014-07间所收集DLBCL病例的临床及病理资料,并辅以免疫组化及原位杂交分析。结果共收集154例DLBCL,125例具有完整的临床病理资料;组织学显示大部分为中心母细胞样;原位杂交显示13例DLBCL表达EBV(10.4%);Cox回归分析显示,EBV感染与患者年龄(≥60)、B症状(有)、结外累及的部位(≥2)、Ann Arbor分级(Ⅲ+Ⅳ)、IPI评分(2~5)显著相关(P<0.05);且患者5年总体生存率与BEV的感染有显著关系(P=0.000)。结论 EBV的感染与DLBCL患者年龄、B症状、结外累及的部位、分级、IPI评分密切相关,EBV+DLBCL患者与EBV-DLBCL患者相比具有更差的预后。
Objective To investigate the clinicopathological features of EBV-positive diffuse large B-cell lymphoma (EBV + DLBCL) in elderly patients. Methods The clinical and pathological data of DLBCL cases collected during 2010-01-2014-07 were retrospectively analyzed and analyzed by immunohistochemistry and in situ hybridization. Results A total of 154 cases of DLBCL were collected, of which 125 cases had complete clinicopathological data. Histology showed that most of the cases were centroblastic. In situ hybridization showed that 13 cases of DLBCL expressed EBV (10.4%). Cox regression analysis showed that EBV infection was associated with patients Age (≥60), symptoms of B (with), extracranial involvement (≥2), Ann Arbor classification (Ⅲ + Ⅳ) and IPI (2-5) were significantly correlated Overall survival was significantly associated with BEV infection (P = 0.000). Conclusions EBV infection is closely related to age, B symptoms, extracranial involvement site, grade and IPI score in DLBCL patients. EBV + DLBCL patients have worse prognosis than EBV-DLBCL patients.