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[目的]观察生金平喘汤治疗小儿毛细支气管炎疗效。[方法]使用随机平行对照方法,将80例住院患儿按病志号抽签方法简单随机分为两组。对照组40例吸氧、解痉平喘、纠正酸碱平衡、抗感染等对症处理。治疗组40例生金平喘汤(太子参,白术各15g,黄芩、茯苓、半夏、陈皮各6g,生姜5g,紫菀4g,麻黄、射干、款冬花、杏仁、芥子、桔梗各2g)1剂/d,水煎60m L,3次/d,口服。连续治疗7周为1疗程。观测临床症状、尿白三烯(LTE4)、肿瘤坏死因子(TNF-α)、复发率、不良反应。治疗1疗程,判定疗效。随访6个月,观测尿白三烯(LTE4)、肿瘤坏死因子(TNF-α)、复发率。[结果]治疗组显效19例,有效9例,无效2例,总有效率95.00%。对照组显效18例,有效14例,无效8例,总有效率80.00%。治疗组疗效优于对照组(P<0.05)。尿LTE4和血TNF-α两组均有改善(P<0.05,P<0.01),治疗组改善优于对照组(P<0.05,P<0.01)。治疗组复发3例,对照组复发10例,治疗组低于对照组(P<0.05)。[结论]生金平喘汤治疗小儿毛细支气管炎,疗效满意,无副作用,值得推广。
[Objective] To observe the effect of Sheng Jin Ping Chuan Decoction in treating bronchiolitis in children. [Methods] Using randomized parallel control method, 80 hospitalized children were randomly divided into two groups randomly according to the method of lot drawing. Control group, 40 cases of oxygen, spasm and asthma, correct acid-base balance, anti-infection symptomatic treatment. The treatment group 40 cases of Jin Jinpingchu soup (Radix Psidium, Atractylodes 15g, Scutellaria, Poria, Pinellia, dried tangerine peel 6g, ginger 5g, Aster 4g, Ephedra, Shegan, Coltsfoot, almonds, mustard, Campanulaceae 2g) / d, decoction 60m L, 3 times / d, orally. Continuous treatment for 7 weeks for a course of treatment. The clinical symptoms, urinary leukotriene (LTE4), tumor necrosis factor (TNF-α), relapse rate and adverse reactions were observed. Treatment of a course of treatment to determine the efficacy. The patients were followed up for 6 months. Urinary leukotriene (LTE4), tumor necrosis factor (TNF-α) and recurrence rate were observed. [Result] The treatment group was effective in 19 cases, effective in 9 cases, ineffective in 2 cases, the total effective rate was 95.00%. In the control group, 18 cases were markedly effective, 14 cases were effective, 8 cases were ineffective, and the total effective rate was 80.00%. The treatment group was better than the control group (P <0.05). Urine LTE4 and blood TNF-αwere improved in both groups (P <0.05, P <0.01), the treatment group improved better than the control group (P <0.05, P <0.01). The treatment group recurred in 3 cases, the control group recurred in 10 cases, the treatment group was lower than the control group (P <0.05). [Conclusion] Sheng Jin Ping Chuan Tang treatment of children with bronchiolitis, satisfactory results, no side effects, it is worth promoting.