Objective: The purpose of this study was to address the issues that occur during the B-ultrasound guided peripherally inserted central catheter(PICC) process and to give a summary of the effective management to these issues accordingly.Methods: The information was collected retrospectively on all of the 1950 PICCs inserted during the 2-year period from July 2013 to July 2015. PICC catheter insertion was performed using the Seldinger approach and was delivered from the basilic vein to the superior vena cava in a B-ultrasound guided manner. Moreover, the point raised during the PICC process would be treated immediately.Results: All of the PICCs were inserted successfully. The problems encountered are shown in the inserted central catheter(PICC) process, such as failures of venipuncture, the problem of inserting guide wire, the catheter was dif?cult to be delivered etc.Conclusions: The B-ultrasound guided approach enhanced the average success regarding the PICC insertion, particularly for the subset with a poor condition in the elbow super?cial vein. Due to the items that emerged in the PICC process, the effective prevention prior to surgery and treatment during the operation would be necessary. Objective: The purpose of this study was to address the issues that occur during the B-ultrasound guided peripherally inserted central catheter (PICC) process and to give a summary of the effective management to these issues accordingly. Methods: The information was collected retrospectively on all of the 1950 PICCs inserted during the 2-year period from July 2013 to July 2015. PICC catheter insertion was performed using the Seldinger approach and was delivered from the basilic vein to the superior vena cava in a B- the point raised during the PICC process would be treated immediately. Results: All of the PICCs were inserted successfully. Results of All of the PICCs were inserted successfully. The problem encountered are shown in the inserted central catheter (PICC) process, such as failures of venipuncture, the problem of inserting guidewire, the catheter was dif? cult to be delivered etc. Con clusions: The B-ultrasound guided approach enhanced the average success regarding the PICC insertion, particularly for the subset with a poor condition in the elbow super? cial vein. Due to the items that emerged in the PICC process, the effective prevention prior to surgery and treatment during the operation would be necessary.