补体是体液免疫系统的重要效应因子,参与炎症应答和抵抗微生物感染。胎儿合成补体的证据至今仍依据早、中期流产胎儿物质的体外研究。在含有标记氨基酸的培养液中培养胎儿组织,证实C3、C4在肝、腹腔和肺泡细胞中合成。用特异性抗体或溶血功能检测证实母体与胎儿水平无相关性也间接证实胎儿合成补体。应用胎儿镜检术和脐带穿刺术等先进方法检测胎儿血标本,可直接检查和比较胎儿、羊水与母体的某些补体成份及调节蛋白水平。作者检测了55例追溯确诊为正常单胎妊娠的妇女,并经胎儿镜检或脐带穿刺以排除血液病和染色体缺陷,以末次月经第一天计算孕龄或经超声照相 Complement is an important effector of humoral immune system, involved in inflammation response and resistance to microbial infection. Fetal evidence of fetal complement synthesis is still based on early and midterm abortion of fetal substances in vitro studies. Fetal tissues were cultured in medium containing labeled amino acids and confirmed that C3 and C4 were synthesized in liver, peritoneal and alveolar cells. Using specific antibodies or hemolytic tests confirmed that maternal and fetal levels have no correlation also indirectly confirmed fetal synthesis of complement. Application of fetal microscopy and umbilical cord puncture and other advanced methods of detection of fetal blood samples can be directly checked and compared fetuses, amniotic fluid and maternal certain complement components and regulatory protein levels. The authors examined 55 women who had been retrospectively diagnosed as having normal singleton pregnancies and had undergone fetal microscopy or umbilical cord puncture to exclude hematological and chromosomal defects and to calculate gestational age on the first day of the last menstruation or by ultrasonography