Nephrin 为肾小球足突细胞裂孔隔膜的重要组成成分,在维持肾小球滤过屏障的结构和功能方面起关键作用。研究发现 nephrin 分布和表达异常将导致不同程度蛋白尿,糖尿病肾病中蛋白尿也与 nephrin 异常有关。阻断肾素-血管紧张素系统可缓解蛋白尿并恢复 Nephrin 的正常表达,这可能是血管紧张素转移酶抑制剂及血管紧张素受体阻断剂缓解蛋白尿的机制之一。 Nephrin is an important component of the glomerular punctate cell fissure septum and plays a key role in maintaining the structure and function of the glomerular filtration barrier. The study found that nephrin distribution and abnormal expression will lead to varying degrees of proteinuria, diabetic nephropathy proteinuria and nephrin abnormalities. Blocking the renin-angiotensin system can relieve proteinuria and restore normal expression of Nephrin, which may be one of the mechanisms by which angiotensin-converting enzyme inhibitors and angiotensin receptor blockers relieve proteinuria.