磷脂酰肌醇3激酶(PI3K)/蛋白激酶B(PKB)信号通路是许多生长因子、细胞因子等的下游信号传导通路,通过抑制细胞凋亡,促进细胞生长、增殖、迁移、侵袭和肿瘤血管生成而与肿瘤发生发展密切相关。许多与子宫内膜癌相关的因素通过PI3K/PKB通路参与肿瘤发生发展,这为子宫内膜癌病因学研究及寻找新的治疗靶点提供了新思路。 The phosphatidylinositol 3 kinase (PI3K) / protein kinase B (PKB) signaling pathway is a downstream signaling pathway for many growth factors, cytokines and the like and promotes cell growth, proliferation, migration, invasion and tumor blood vessels by inhibiting apoptosis Generated and closely related to tumor development. Many factors related to endometrial cancer are involved in tumorigenesis through the PI3K / PKB pathway, which provides a new idea for the etiology of endometrial cancer and the search for new therapeutic targets.