氧化胆固醇(Oxch)是胆固醇经氧化后产生的一系列氧化产物。在空气中,胆固醇和其它许多物质一样,可以自身氧化(autoxidation)生成不同的Oxch。有关Oxch的研究,最早起始于1895年Lifschützt的工作。到了1967年,Smith等首次用硅胶板薄层层析法分离出32种不同的Oxch。此后,这方面的工作有了很大的进展。很多研究表明,Oxch在理化性质与生物学功能上都和胆固醇有许多明显的不同。Oxch能抑制酶活性,抑制胆固醇的生物合成,抑制细胞的DNA合成,具有细胞毒、血管毒作用,具有致突变性与致癌性。1976年,Peng等人开始研究Oxch与动脉粥样硬化的 Oxidation of cholesterol (Oxch) is a series of oxidation products of cholesterol oxidation. In the air, cholesterol, like many other substances, can autoxidize to produce different Oxch. Oxch’s research began as early as 1895 in Lifschützt’s work. By 1967, Smith et al. First isolated 32 different Oxch layers using silica gel thin layer chromatography. Since then, great progress has been made in this area. Many studies show that Oxch has many obvious differences from cholesterol in its physicochemical properties and biological functions. Oxch can inhibit enzyme activity, inhibit cholesterol biosynthesis, inhibit cell DNA synthesis, with cytotoxic, vascularization, mutagenic and carcinogenic. In 1976, Peng et al began to study Oxch and atherosclerosis