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人乳头瘤病毒58型(HPV58)是具有高度致癌危险性的HPV型别之一,在亚洲和非洲等地呈现出特殊的流行状况.由于全球HPV58数据分布零散,加之一些高发地区(如中国内地)数据缺乏,迄今为止尚未有对世界范围内HPV58地理分布的全面分析.本研究对中国内地妇女宫颈癌组织标本进行了HPV58检测,共获得14条HPV58-E6,L1基因序列.对GenBank收录的自1985年起分离的HPV58序列进行了系统地理学分析.结果表明,在上海、江苏和四川等地检出的HPV58-E6,L1序列均与以往来自中国香港、西安和日本等HPV58亚洲株同源.HPV58毒株可能由非洲西部起源,而中国内地及东南亚地区则在接受“根部”来源的变异株之后,成为毒株播散源“中转站”和新的策源地.HPV58型可能与HPV16,HPV18相同,也是宫颈癌发生和散播的主要HPV型别.
Human papillomavirus type 58 (HPV58) is one of the most highly carcinogenic HPV genotypes and presents a special epidemic in Asia and Africa, etc. Due to the fragmented distribution of HPV58 worldwide and the high incidence of HPV58 ) Data, and so far there is no comprehensive analysis of the geographic distribution of HPV58 in the world.In this study, HPV58 was detected in specimens of cervical cancer from women in mainland China, and a total of 14 HPV58-E6 and L1 gene sequences were obtained. The phylogeography analysis of the HPV58 sequences isolated since 1985 showed that HPV58-E6 and L1 sequences detected in Shanghai, Jiangsu and Sichuan provinces were similar to the HPV58 strains previously reported in Hong Kong, Xi’an and Japan The source of HPV58 strain may originate from western Africa, while the mainland of China and Southeast Asia will become the source of transmission of the strain and the new source after accepting the mutants of “root” origin. May be the same with HPV16, HPV18, but also the main HPV types that occur and spread cervical cancer.