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目的:了解农村高脂血症患者服用辛伐他汀后血清肌酸激酶(Creatine Kinase,CK)的变化及其主要影响因素。方法:安徽农村社区高脂血症患者,在饮食控制治疗4周后,血清胆固醇水平仍≥5.72 mmol/L者,给予辛伐他汀20 mg每晚顿服,分别于治疗前及治疗后4周、8周检测血脂、肝功能和血清CK等。结果:(1)服药4周后,患者CK均值明显高于服药前(P<0.01),平均升高约为88.5%。(2)多元逐步回归分析显示,影响患者服药后CK升高的主要因素为服药前的CK水平和体力劳动强度。(3)分层分析显示体力劳动强度越大,CK升高越明显(P>0.01)。结论:农村高脂血症患者服用辛伐他汀会引起血清CK短暂性升高,在服药期间体力劳动强度将会影响CK的升高。
Objective: To investigate the changes of serum creatine kinase (CK) and its main influencing factors after taking simvastatin in rural patients with hyperlipidemia. Methods: Patients with hyperlipidemia in rural areas of Anhui Province were treated with simvastatin 20 mg per night for 4 weeks after dietary control and serum cholesterol was still ≥5.72 mmol / L, respectively. Before and 4 weeks after treatment , 8 weeks detection of blood lipids, liver function and serum CK and so on. Results: (1) After 4 weeks of treatment, the average value of CK was significantly higher than that before treatment (P <0.01), with an average increase of about 88.5%. (2) Multivariate stepwise regression analysis showed that the main factors influencing the increase of CK in patients after taking the medicine were the CK level and manual labor intensity before taking medicine. (3) Hierarchical analysis showed that the greater the physical labor intensity, the more obvious the increase of CK (P> 0.01). Conclusion: Simvastatin in rural patients with hyperlipidemia may cause a transient elevation of serum CK, and the strength of physical labor during the medication will affect the increase of CK.