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目的探讨低+Gz预适应对高+Gz应激大鼠脑组织神经元形态的影响。方法 36只SD大鼠随机分为对照组、+10 Gz应激组和低+Gz预适应组,分别于+10 Gz暴露后24 h麻醉取脑,采用光镜和电镜对大鼠皮层、海马进行观察分析。结果 +10 Gz应激暴露后,在皮层、海马可见变性的神经元及超微结构损伤,低+Gz预适应组的神经元及超微结构损伤要轻于+10 Gz组。结论低+Gz预适应可以减轻高+Gz应激所引起的大鼠脑病理损伤。
Objective To investigate the effects of low + Gz preconditioning on neuronal morphology in brain of high + Gz stressed rats. Methods Thirty - six SD rats were randomly divided into control group, +10 Gz stress group and low + Gz preconditioning group. The rats were anesthetized 24 hours after exposure to +10 Gz, and the rats were sacrificed by light and electron microscope. For observation and analysis. Results After exposure to +10 Gz stress, degeneration of neurons and ultrastructural damage were observed in the cortex and hippocampus. Neurons and ultrastructural damage in the + Gz preconditioning group were weaker than those in the +10 Gz group. Conclusions Low + Gz preconditioning can reduce the pathological damage of rat brain induced by high + Gz stress.