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目的 :观察盐酸恩丹西酮的不同用法防治肿瘤化疗所致恶心、呕吐的疗效。方法 :对 119例恶性肿瘤化疗患者随机分成盐酸恩丹西酮 1天用药组 (5 5例 )和 3天用药组 (6 4例 )。 1天用药组在化疗前 15分钟静注恩丹西酮8mg 1次 ,3天用药组在化疗当日及其后 2天每天静注恩丹西酮 8mg 1次。 结果 :含顺铂化疗者 ,1天用药组第 1～ 3天的止呕率分别为 6 9 2 %、5 7 7%、6 9 2 % ,3天用药组第 1～ 3天的止呕率分别为 75 0 %、90 6 %、90 6 % ,二组的第 2、3天的止呕率有明显差异 (P <0 0 5 )。而对不含顺铂化疗者 ,1天用药组和 3天用药组的第 1～ 3天的止呕率分别为89 7%～ 96 9% ,两者无明显差异 (P >0 0 5 )。结论 :含顺铂化疗者 ,化疗日宜使用盐酸恩丹西酮 8mg 2～ 3次 ,化疗后 2天内也应使用盐酸恩丹西酮 ,防治延迟性呕吐发生。非顺铂化疗者 ,在化疗日使用盐酸恩丹西酮 8mg即可。
Objective: To observe the effect of different usage of ondansetron hydrochloride in the treatment of nausea and vomiting caused by chemotherapy. Methods : One hundred and nineteen patients with malignant tumors were randomly divided into an ondansetron hydrochloride 1-day group (55 cases) and a 3-day group (64 cases). In the 1-day treatment group, ondansetron 8 mg was intravenously administered 15 minutes before chemotherapy, and on the 3 days of the treatment group, ondansetron 8 mg was intravenously administered once a day on the day of chemotherapy and 2 days thereafter. Results: For cisplatin-containing chemotherapy patients, the vomiting rates on the 1st to 3rd days of the 1-day treatment group were 696%, 57.77%, and 692%, respectively. The vomiting on the 1st to 3rd days of the 3-day treatment group was observed. The rate of vomiting on the 2nd and 3rd days of the two groups were significantly different (P < 0.05). The rates were 750, 96, and 90.6% respectively. For patients without cisplatin chemotherapy, the vomiting rates for the first to third days of the 1-day and 3-day groups were 89 7% to 96 9%, respectively, with no significant difference between the two groups (P > 0 05). . Conclusion: Chemotherapy with cisplatin should be performed on day 2 or 3 times with ondansetron hydrochloride. Ondansetron hydrochloride should also be used within 2 days after chemotherapy to prevent the occurrence of delayed vomiting. Non-cisplatin chemotherapy was performed on day 8 of chemotherapy with ondansetron hydrochloride.