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慢性乙型肝炎患者肝脏的病理变化特点之一是炎性细胞浸润,包括单核细胞、巨噬细胞等,已有的文献报道这些细胞到达炎症组织需要趋化因子及其受体的作用[1]。已有研究证实,趋化因子的异常表达与病毒性肝炎的进程密切相关。高表达的趋化因子可招募大量效应淋巴细胞清除病毒感染的细胞,但同时趋化因子的过度释放导致炎症反应会加剧肝细胞损伤[2]。我们于2011-2013年对106例慢性乙型肝炎患者进行评价,探讨趋化因子是否可以作为慢性
Chronic hepatitis B patients with pathological features of the liver is characterized by inflammatory cell infiltration, including monocytes, macrophages, etc., the literature has reported that these cells to reach the inflammatory tissue requires the role of chemokines and their receptors [1 ]. Studies have shown that the abnormal expression of chemokines is closely related to the process of viral hepatitis. Highly expressed chemokines can recruit a large number of effector lymphocytes to clear the virus-infected cells, but at the same time the excessive release of chemokines leads to the inflammatory response exacerbating hepatocellular injury [2]. We evaluated 106 patients with chronic hepatitis B from 2011 to 2013 to investigate whether chemokines can be used as chronic