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众所周知,人体内维生素D水平与少年佝偻病和老年骨质疏松直接相关。最近大量流行病学证据还表明,维生素D(VD)缺乏是多种自身免疫性疾病,癌症,心血管疾病,抑郁症,老年痴呆症,感染性疾病,肌肉骨骼功能下降等的危险因素之一。另外,胰岛素抵抗,高血压和高胆固醇血症也与维生素D缺乏有关。因此,合理补充维生素D可以降低多种疾病风险,并对心血管疾病的风险有益。本文系根据已有的研究结论,阐述维生素D水平与多种临床疾病之间的关联,并对人体血清VD浓度合理监测及合理补充的临床意义做一综述。
It is well known that the level of vitamin D in the human body is directly related to juvenile rickets and senile osteoporosis. A number of recent epidemiological evidence also show that vitamin D (VD) deficiency is one of the risk factors for a variety of autoimmune diseases, cancer, cardiovascular disease, depression, Alzheimer’s disease, infectious diseases, musculoskeletal function decline and the like . In addition, insulin resistance, hypertension and hypercholesterolemia are also associated with vitamin D deficiency. Therefore, the rational vitamin D supplementation can reduce the risk of multiple diseases, and the risk of cardiovascular disease benefit. In this paper, based on the existing research conclusions, the relationship between vitamin D levels and various clinical diseases is expounded, and the clinical significance of reasonable monitoring and reasonable supplement of human serum VD concentration is reviewed.