心血管组织能合成及分泌多种生物活性因子,包括血管紧张素、内皮素和肾上腺髓质素等,它们通过旁分泌、自分泌和内分泌等方式调节血管功能,是维持循环稳态的重要因素。在炎症和感染病程中,病原体及炎性因子影响心血管活性多肽的表达和代谢,引起机体全身或局部血流动力学改变。近年来大量研究资料表明心血管活性肽还参与机体免疫调节,在炎症及感染疾病的发病和进程中也具有重要调节意义。例如内皮素诱导多形核白细胞聚集并增加细胞间粘附分子,血管紧张素Ⅱ活化吞噬细胞产生氧自由基及诱导炎症介质表达,脑钠素和神经降压素具有改变 Cardiovascular tissue can synthesize and secrete a variety of bioactive factors, including angiotensin, endothelin and adrenomedullin, which regulate blood vessel function by paracrine, autocrine and endocrine methods, which is an important factor in maintaining circulatory homeostasis . In the course of inflammation and infection, pathogens and inflammatory factors affect the expression and metabolism of cardiovascular active peptides, causing systemic or local hemodynamic changes. In recent years, a large number of research data show that cardiovascular active peptide is also involved in the immune regulation of the body, inflammation and infection in the pathogenesis and progression also has important regulatory significance. For example, endothelin induces polymorphonuclear leukocyte accumulation and increases intercellular adhesion molecule. Angiotensin II activates phagocytes to produce oxygen free radicals and induce the expression of inflammatory mediators. Brain natriuretic peptide and neurotensin have changes