论文部分内容阅读
癌症是一类遗传及表观遗传异常的复杂疾病。宫颈癌由癌前病变发展为侵入性的宫颈癌是由于人乳头瘤病毒(Human Papilloma Virus,HPV)持续感染引起了宿主基因组及表观遗传基因组的改变。表观遗传改变包括DNA甲基化水平改变、mi RNA异常表达、癌基因的激活及抑癌基因沉默等。鉴于mi RNA可被表观遗传机制调控,因而其在宫颈癌中的异常表达可能是启动子甲基化水平改变引起的。基于以上判断,本文对HPV感染、DNA甲基化水平改变及mi RNA异常表达间的关系进行综述,以期揭示表观遗传异常与宫颈癌发生发展之间的关系。
Cancer is a complex class of diseases characterized by genetic and epigenetic abnormalities. Cervical cancer The progression from precancerous lesions to invasive cervical cancer is due to persistent changes in the host genome and epigenetic genome caused by human papilloma virus (HPV) infection. Epigenetic changes include changes in DNA methylation levels, miRNA abnormalities, oncogene activation and tumor suppressor gene silencing. Since miRNAs can be regulated by epigenetic mechanisms, their abnormal expression in cervical cancer may be caused by the change of promoter methylation level. Based on the above judgment, this article reviewed the relationship between HPV infection, DNA methylation level changes and miRNA abnormal expression in order to reveal the relationship between epigenetic abnormalities and the occurrence and development of cervical cancer.